No Evidence of Early Developmental Delay in Juvenile-Onset Huntington's Disease Patients.

ABSTRACT:

Background

Previous studies suggest that early developmental delay is a common feature of Juvenile-Onset Huntington's disease (JOHD), with highest incidence in those with very high CAG repeats (> 80). However, all reports of developmental delay in JOHD are exclusively based on retrospective review of medical charts. Comprehensive assessment of birth history metrics may provide better insight into the question of early life development in JOHD.

Objective

To explore the prevalence of prematurity, birth complications, low birth weight and developmental delay in patients with JOHD in comparison to control participants.

Methods

Parents of patients with JOHD and gene-non-expanded (GNE) control participants from Kids-HD (n = 104) and Kids-JOHD (n = 34, 24% with CAG > 80) stu

SUBMITTER: Olson L 

PROVIDER: S-EPMC11952948 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature