Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease.

ABSTRACT:

Background

The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.

Objectives

To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.

Methods

These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.

Results

Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes a

SUBMITTER: De Santis T 

PROVIDER: S-EPMC11952954 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature