Neutrophil swarming is crucial for limiting oral mucosal infection by Candida albicans.

ABSTRACT: Oral mucosal colonization by Candida albicans is benign in healthy people but progresses to deeper infection, known as oropharyngeal candidiasis, that may become disseminated when combined with immunosuppression. Cortisone use and neutropenia are risk factors for invasive mucosal fungal infections; however, the mechanisms are poorly understood. Here, we identify in vivo neutrophil functional complexes known as swarms that are crucial for preventing C. albicans epithelial invasion. Anti-Ly6G antibody treatment impaired swarm formation and increased fungal infection depth, confirming the role of neutrophil swarms in limiting C. albicans invasion. Neutrophil swarm function could be disrupted by administration of resolvins, and required BLT1 (leukotriene B4 receptor 1) expression so that admin

SUBMITTER: Saraswat D 

PROVIDER: S-EPMC11953071 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature