Functional Outcome Prediction of Acute Ischemic Stroke Based on the Oral and Gut Microbiota.

ABSTRACT: Although several studies have identified a distinct gut microbiota in individuals with acute ischemic stroke (AIS), there is a limited amount of research that has simultaneously investigated alterations in the oral and intestinal microbiota in AIS patients and their correlation with clinical prognosis. This was a prospective and observational single-center cohort study in which we included 160 AIS patients who were admitted within 24 h after a stroke event. We collected oral and rectal swab samples for analysis using 16S rRNA high-throughput sequencing. Our study revealed that patients with unfavorable outcomes after AIS showed early disruptions in their oral and intestinal microbiota. Rectal swabs showed increased levels of facultatively anaerobic bacteria in patients with a poor prognosi

SUBMITTER: Liang J 

PROVIDER: S-EPMC11953115 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature