Carbohydrate intake and activation of gastric acid secretion decrease gastric estrogen secretion.

ABSTRACT: Gastric parietal cells (gastric acid-secreting cells) secrete estrogen in response to blood lipid (triglycerides [TG] and fatty acids [FFA]) levels. Since estrogen helps reduce blood lipid levels, gastric estrogen would be important in lowering elevated blood lipid levels. However, gastric parietal cells use lipid-derived energy for estrogen production and acid secretion. Thus, postprandial changes in blood lipid levels and acid secretion could affect gastric estrogen production. Here, we show that blood estrogen and FFA decrease after meals, especially after carbohydrate intake. Postprandially decreased blood estrogen levels are partially restored by intravenous lipid injections. Hormones that activate and suppress gastric acid secretion decrease and increase estrogen production in isolat

SUBMITTER: Ito T 

PROVIDER: S-EPMC11953264 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature