Association between urinary volatile organic compound metabolites and sarcopenia in the US general population: a cross-sectional NHANES study from 2011 to 2018.

ABSTRACT: Volatile organic compound (VOC) is a prevalent form of pollutant that has been linked to various human ailments, yet their connection to sarcopenia remains uncertain. This study seeks to examine the potential association between exposure to mixtures of metabolites of volatile organic compounds (mVOCs) and sarcopenia, while also investigating the potential mediating effects of oxidative stress and inflammation. Data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) were utilized for the analysis of the relationship between mVOCs and sarcopenia through logistic regression. The least absolute shrinkage and selection operator (LASSO) regression model was employed to identify key mVOCs, while the quantile-g computation model (qgcomp) and bayesian kernel machine regres

SUBMITTER: Tang W 

PROVIDER: S-EPMC11953313 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature