Monocyte CCL2 signaling possibly contributes to increased asthma susceptibility in type 2 diabetes.

ABSTRACT: In recent years, the respiratory system has been increasingly recognized as a key target organ in diabetes. Although observational studies have established significant clinical associations between type 2 diabetes (T2D), antidiabetic medication use, and asthma, the causal relationships and underlying molecular mechanisms remain unclear. This study employed a bidirectional two-sample Mendelian randomization (MR) approach combined with bioinformatics analysis to explore the causal relationships between T2D and asthma subtypes and complications, with a focus on immune-regulatory mechanisms. The MR analysis utilized inverse-variance weighted (IVW) and meta-analysis methods to evaluate overall effects, with sensitivity analyses confirming the robustness of the findings. Bioinformatics analysis

SUBMITTER: Luo T 

PROVIDER: S-EPMC11953320 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature