Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson's disease.

ABSTRACT: Growing evidence highlights the roles of glymphatic system and peripheral inflammation in Parkinson's disease (PD). We evaluated their interrelationship and potential mechanisms contributing to motor symptoms using DTI-ALPS and inflammatory markers (leukocyte, lymphocyte, neutrophil counts, neutrophil-to-lymphocyte ratio [NLR], and platelet-to-lymphocyte ratio [PLR]) in 134 PD patients (52 tremor-dominant [TD], 62 postural instability and gait difficulty [PIGD]) and 81 healthy controls (HC, 33 with inflammatory markers). PD exhibited lower DTI-ALPS than HC (1.43 ± 0.19 vs. 1.52 ± 0.21, p = 0.001). DTI-ALPS was negatively correlated with NLR, PLR, and neutrophils in PD (all p < 0.05) and with neutrophils in PIGD (β = -0.043, p = 0.048), and positively correlated with lymphocytes in TD (β = 

SUBMITTER: Lin R 

PROVIDER: S-EPMC11953377 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature