Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study.

ABSTRACT: Although lipid biology may play a key role in the pathophysiology of mental health disorders such as schizophrenia (SCZ) and bipolar disorder (BD), the nature of this interplay and how it could shape phenotypic presentation, including cognitive performance is still incompletely understood. To address this question, we analyzed the association of plasma level of different lipid species with cognitive performance in the transdiagnostic PsyCourse Study. Plasma lipidomic profiles of 623 individuals (188 SCZ, 243 BD, 192 healthy controls) belonging to the PsyCourse Study were assessed using liquid chromatography and untargeted mass spectrometry. The association between 364 annotated lipid species from 16 lipid classes and six cognitive tests was evaluated. Likewise, the association of polygenic

SUBMITTER: Oraki Kohshour M 

PROVIDER: S-EPMC11953450 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature