A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases.

ABSTRACT: Lung and gastrointestinal diseases often occur together, leading to more adverse health outcomes than when a disease of one of these systems occurs alone. However, the potential genetic mechanisms underlying lung-gastrointestinal comorbidities remain unclear. Here, we leverage lung and gastrointestinal trait data from individuals of European, East Asian and African ancestries, to perform a large-scale genetic cross trait analysis, followed by functional annotation and Mendelian randomization analysis to explore the genetic mechanisms involved in the development of lung-gastrointestinal comorbidities. Notably, we find significant genetic correlations between 27 trait pairs among the European population. The highest correlation is between chronic bronchitis and peptic ulcer disease. At the v

SUBMITTER: You D 

PROVIDER: S-EPMC11953465 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature