Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection.

ABSTRACT: Fatty acid synthase (FASN) has been shown to be critical in the replication of several viruses of the genus Orthoflavivirus. In this study the role two inhibitors of FASN that work through different mechanisms were investigated in dengue virus (DENV) and Zika virus (ZIKV) infections. Triclosan is a FASN inhibitor that targets the enol reductase domain of FASN, while lapatinib exerts an effect on FASN through acting on HER2, an upstream regulator of FASN. After determining cytotoxicity, a comprehensive analysis of the effect of these drugs in DENV 2 and ZIKV infection was undertaken. The results showed that triclosan had moderate antiviral activity against both DENV 2 (EC₅₀ = 10.21 µM; Selective index (SI) = 3.99) and ZIKV ( EC₅₀ = 22.84 µM; SI = 5.49). Lapatinib had r

SUBMITTER: Sornprasert S 

PROVIDER: S-EPMC11953471 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature