The Persistence of Sex Bias in High-Impact Clinical Research.

ABSTRACT:

Introduction

Sex bias is present in clinical research resulting in disparities in the treatment of women. Our objective was to identify the prevalence of sex inclusiveness of participants in human clinical trials after the passage of National Institutes of Health (NIH) and United States Congress policies in 2015 and 2016 to increase female enrollment in clinical research.

Methods

We performed an observational analysis of data from registered clinical trials published in three high-impact biomedical journals from January 1, 2015 to December 31, 2019.

Results

One thousand four hundred and forty two manuscripts with 4,765,783 human subjects were included for analysis. Significantly more males (56%) than females (44%) were included in all three journals (P < 0.0001). Sex

SUBMITTER: Barlek MH 

PROVIDER: S-EPMC11953574 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature