Metal Concentrations in Blood and Cerebrospinal Fluid of Patients With Arthroplasty Implants.

ABSTRACT:

Importance

Arthroprosthetic metal exposure has been linked to neurological dysfunction, but evidence of central nervous system exposure is largely missing.

Objective

To compare levels of all arthroplasty-relevant metals in cerebrospinal fluid (CSF), whole blood, and serum of patients with and without large joint replacement.

Design, setting, and participants

The NeuroWear pilot study was a single-site hospital-based cross-sectional study conducted between April 2018 and November 2019. Laboratory personnel and investigators were blinded to group allocation. Patients presenting for elective surgery under spinal anesthesia and patients scheduled for lumbar puncture at a university medical center were eligible for inclusion. Patients aged 18 years and older with at least

SUBMITTER: Rakow A 

PROVIDER: S-EPMC11953760 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature