Enhanced anticancer effect of carfilzomib by codelivery of calcium peroxide nanoparticles targeting endoplasmic reticulum stress.

ABSTRACT: Encouraged by the clinical success of proteasome inhibitors treating hematological malignancy, continuous efforts are being made to improve their efficacy and expand their applications to solid tumor therapy. In this study, liposomes were used to encapsulate the proteasome inhibitor carfilzomib (CFZ) and calcium peroxide (CaO₂) nanoparticles for effective combination therapy targeting the interplay between calcium overload and oxidative stress. Low-dose CaO₂ synergistically enhances the anticancer effect of CFZ in the human glioblastoma U-87 MG cells. The reactive oxygen species (ROS) generation and glutathione depletion by low-dose CaO₂ complement CFZ-induced ubiquitinated protein accumulation further triggering endoplasmic reticulum (ER) stress leading to

SUBMITTER: Yin D 

PROVIDER: S-EPMC11953955 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature