Tapping natures rhythm: the role of season in mitochondrial function and genetics in the UK biobank.

ABSTRACT:

Background

Mitochondria are small organelles inside our cells crucial for producing energy and heat, cell signaling, production and degradation of important molecules, as well as cell death. The number of mitochondria in each cell is a marker for mitochondrial function, which generally declines with increasing age. However, we found that there is also a considerable seasonal variation of mitochondrial abundance, which warrants further research.

Methods

We leveraged data from individuals participating in the UK Biobank study and computed their mitochondrial abundance from Exome sequencing reads mapping to the mitochondrial genome. The seasonal effect was modelled as a sine-cosine function across the year and changes in amplitude, acrophase and displacement of mitochondrial ab

SUBMITTER: Papadam A 

PROVIDER: S-EPMC11954186 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature