Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder.

ABSTRACT:

Background

Despite the power and promise of early detection and treatment in autism spectrum disorder (ASD), early-life biomarkers are limited. An early-life risk biosignature would advance the field's understanding of ASD pathogenies and targets for early diagnosis and intervention. We therefore sought to add to the growing ASD biomarker literature and evaluate whether fetal metabolomics are altered in idiopathic ASD.

Methods

Banked cord blood plasma samples (N = 36 control, 16 ASD) were analyzed via gas chromatography and mass spectrometry (GC-MS). Samples were from babies later diagnosed with idiopathic ASD (non-familial, non-syndromic) or matched, neurotypical controls. Metabolite set enrichment analysis (MSEA) and biomarker prediction were performed (MetaboAnalyst).

SUBMITTER: Gumusoglu SB 

PROVIDER: S-EPMC11954230 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature