Chemical profiling and mechanistic insights into the antibacterial efficacy of Melaleuca cajuputi leaf extract.

ABSTRACT:

Background

The emergence of antimicrobial resistance and the prevalence of bacterial infections have prompted the search for novel antimicrobials with diverse therapeutic potential from natural products. Thus, this study investigated the antibacterial efficacy of the leaf extracts of M. cajuputi. Additionally, the chemical composition and the mechanism of action of the most active extract (MAE) were evaluated.

Methods

The antibacterial activity of leaf extracts of M. cajuputi was assessed using the broth microdilution assay. Scanning electron microscopy (SEM) was used to investigate the effects of MAE on the morphology of bacterial cells. Meanwhile, the chemical composition of the MAE was analyzed using Fourier transform infrared (FTIR) spectroscopy and gas chromatography-ma

SUBMITTER: Isah M 

PROVIDER: S-EPMC11954241 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature