Culturomics of the pig tonsil microbiome identifies new species and an untapped source of novel antimicrobials.

ABSTRACT:

Background

In humans and pigs, altered composition of the microbiota associated with the epithelium of the palatine tonsils has been associated with bacterial or viral infection and lymphoid tissue inflammation. Tonsil lymphoid tissue is important for immunity and considered an important portal of entry for pathogens such as Streptococcus suis. Little is known about correlations between tonsil-associated microbiota, tonsillar infections, and the species that might confer colonization resistance against pathogens. Here, we describe a large collection of representative bacterial species from the tonsil surface biofilm and used genome mining and in vitro assays to assess their potential as probiotics to reduce infections by S. suis and other pathogens.

Results

Data on tonsil mi

SUBMITTER: de Oliveira IMF 

PROVIDER: S-EPMC11954270 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature