Association between proton pump inhibitor use and migraine: a systematic review and meta-analysis.

ABSTRACT:

Background

Migraine is a common neurological disorder with potential pharmacological triggers. Proton pump inhibitors (PPIs), commonly prescribed for managing gastroesophageal reflux disease and other acid-related gastrointestinal disorders, have been linked to headaches. However, their association with migraine remains unclear. This systematic review and meta-analysis assessed the association between PPI use and the incidence of migraine.

Method

A systematic search of PubMed, Embase, and Web of Science was conducted in accordance with the PRISMA framework and registered with PROSPERO (ID: CRD42025644604) to enhance transparency. The search, conducted up to January 2024, included studies focusing on the association between migraine and PPI use. Data screening and extraction

SUBMITTER: Satapathy P 

PROVIDER: S-EPMC11954283 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature