The dual role of titanium particles in osteolysis: implications for gene therapy in prosthesis loosening.

ABSTRACT:

Background

Aseptic prosthesis loosening caused by wear particles is a major complication in patients with osteoarthritis following total joint replacement. Despite advancements in treatment, the underlying mechanisms remain poorly understood, and effective therapies are still lacking.

Methods

In this study, we investigated the effects of titanium particles on osteoclast and osteoblast differentiation through both in vitro and in vivo experiments.

Results

Our findings revealed that titanium particles not only promote the differentiation of RAW264.7 cells into osteoclasts and enhance the secretion of inflammatory factors but also inhibit the differentiation of BMSCs into osteoblasts and reduce the expression of Wnt signaling pathway-related factors. Furthermore, using a

SUBMITTER: Chen P 

PROVIDER: S-EPMC11954349 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature