EGCG's anticancer potential unveiled: triggering apoptosis in lung cancer cell lines through <i>in vitro</i> investigation.

ABSTRACT:

Background

Novel treatment techniques are needed since lung cancer is still a major worldwide health concern. Green tea contains a component called epigallocatechin-3-gallate (EGCG), which has demonstrated potential anticancer properties. This work sought to understand how EGCG affects the phosphatidylinositol-3-kinase protein kinase B (PI3K/Akt) signaling pathway, which in turn causes apoptosis in H1299 lung cancer cells.

Methods

In this experiment, multiple dosages of EGCG were applied to five H1299 cells and five A549 cell lines for a duration of 72 h. Apoptotic pathways, cellular responses, and protein expression levels were investigated in relation to EGCG by morphological, biochemical, and proliferation/migration investigations.

Results

In H1299 and A549 cells,

SUBMITTER: Khair AMB 

PROVIDER: S-EPMC11954466 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature