Triage performance of DNA methylation for women with high-risk human papillomavirus infection.

ABSTRACT:

Objective

DNA methylation is a promising biomarker for cervical cancer screening. This study aimed to validate the triage performance of cytological DNA methylation for detecting cervical intraepithelial neoplasia of grade 3 or worse (CIN3+) in women with high-risk human papillomavirus (hrHPV) infection from a large prospective cohort undergoing opportunistic screening in China (METHY3).

Methods

The triage performance for detecting CIN3+ lesions was compared between HPV16/18 genotyping, a liquid-based cytology (LBC) test, and the PAX1 and JAM3 methylation (PAX1m/JAM3m) test according to cervical pathologic outcomes. Among the 4394 women infected with hrHPV, 1105 had definitive cervical histological findings that were analyzed.

Results

For detecting CIN3+, the specific

SUBMITTER: Kong L 

PROVIDER: S-EPMC11954506 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature