Clinical Efficacy and Safety of Botulinum Toxin A Injection into the Bulbospongiosus Muscle for Treating Lifelong Premature Ejaculation: A Systematic Review and Meta-Analysis.

ABSTRACT: Botulinum toxin A (BoNT/A) injections into the bulbospongiosus muscle have emerged as a novel treatment for lifelong premature ejaculation (PE), though efficacy remains controversial. This study evaluates BoNT/A's efficacy and safety through a comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials.gov, and ISRCTN registry. We included randomized controlled trials, prospective, and retrospective studies, focusing on intravaginal ejaculation latency time (IELT) and adverse events. Four studies (three meta-analyzed) involving 263 patients were analyzed. BoNT/A increased IELT by 37.87 s at 1 month (MD, 37.87; 95% CI, -2.86 to 78.59; p = .07; I² = 96%), 11.52 s at 3 months (MD, 11.52; 95% CI, -16.91 to 39.94; p = .43; I

SUBMITTER: Gao D 

PROVIDER: S-EPMC11954517 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature