Mild traumatic brain injury increases cortical iron: evidence from individual susceptibility mapping.

ABSTRACT: Quantitative susceptibility mapping has been applied to map brain iron distribution after mild traumatic brain injury to understand properties of neural tissue which may be related to cellular dyshomeostasis. However, this is a heterogeneous injury associated with microstructural brain changes, and 'traditional' group-wise statistical approaches may lead to a loss of clinically relevant information, as subtle alterations at the individual level can be obscured by averages and confounded by within-group variability. More precise and individualized approaches are needed to characterize mild traumatic brain injury better and elucidate potential cellular mechanisms to improve intervention and rehabilitation. To address this issue, we use quantitative MRI to build individualized profiles of reg

SUBMITTER: Essex CA 

PROVIDER: S-EPMC11954555 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature