Unveiling spontaneous renal tubule-like structures from human adult renal progenitor cell spheroids derived from urine.

ABSTRACT: The rapidly developing field of renal spheroids and organoids has emerged as a valuable tool for modeling nephrotoxicity, kidney disorders, and kidney development. However, existing studies have relied on intricate and sophisticated differentiation protocols to generate organoids and tubuloids, necessitating the external administration of multiple growth factors within precise timeframes. In our study, we demonstrated that human adult renal progenitor cells (ARPCs) isolated from the urine of both healthy subjects and patients can form spheroids that naturally generated very long tubule-like structures. Importantly, the generation of these tubule-like structures is driven solely by ARPCs, without the need for the external use of chemokines or growth factors to artificially induce this proce

SUBMITTER: Giannuzzi F 

PROVIDER: S-EPMC11954590 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature