Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene <i>Zeste White 10</i> in Hepatocellular Carcinoma.

ABSTRACT:

Background

Tyrosine kinase inhibitors (TKIs) are first-line therapies for hepatocellular carcinoma (HCC), but the drug resistance restricts the long-term clinical outcomes. This study aimed to investigate the expression patterns and possible clinical significance of a TKI-resistant gene zeste white 10 (ZW10) in HCC.

Methods

Clustered regularly interspaced short palindromic repeats (CRISPR) screening was conducted to obtain TKI-resistant genes. Pan-cancer analysis was employed to analyze the expression landscape of the critical TKI-resistant gene ZW10. Transcriptional expression data for ZW10 were obtained from 76 centers, including 3,312 HCC samples and 2,703 noncancerous tissues. A summary receiver operating characteristic (SROC) curve was built

SUBMITTER: Huang QL 

PROVIDER: S-EPMC11954606 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature