Detection of Hematological Malignancies Using N-NOSE (Nematode-NOSE).

ABSTRACT: Hematological malignancies often lack defined risk factors and present with non-specific symptoms, underscoring the urgent need for simple and reliable detection methods. To address this challenge, Hirotsu et al. innovated N-NOSE, a novel, non-invasive cancer screening test that utilizes the chemotaxis response of the nematode Caenorhabditis elegans to detect tumor-related odors in urine. In this clinical study, we assessed the performance of N-NOSE in patients with various hematological malignancies at diagnosis and during treatment. Urine samples were collected from 30 healthy individuals and 89 patients, including those with leukemia (n = 13), malignant lymphoma (n = 53), multiple myeloma (n = 15), primary AL amyloidosis (n = 3), Waldenström's macroglobulinemia (n = 2), myelodysplastic

SUBMITTER: Nakamura S 

PROVIDER: S-EPMC11954616 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature