Reorganization of brain connectivity in post-COVID condition: a ¹⁸F-FDG PET study.

ABSTRACT:

Background

A hypometabolic brain pattern has been reported in patients with post-COVID condition (PCC). The aim of this study was to investigate reorganization in metabolic connectivity in patients with PCC.

Results

One hundred eighty-eight patients who underwent brain ¹⁸F-FDG PET for PCC were retrospectively included from two university hospital centres. These patients were age- and sex-matched to 120 healthy controls who underwent brain ¹⁸F-FDG PET before the COVID-19 outbreak. A voxel-based group comparison between patients and controls was performed (p-voxel at 0.005 uncorrected, p-cluster at 0.05 FWE corrected). Interregional correlation analyses of the identified clusters as well as sparse inverse covariance estimations at whole-brain scaling were

SUBMITTER: Verger A 

PROVIDER: S-EPMC11954761 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature