Quantifying CD73 expression after chemotherapy or chemoradiotherapy in esophageal squamous cell carcinoma.

ABSTRACT:

Background

CD73 and CD39, key components of the adenosine axis, are expressed in multiple malignancies; the impact of standard-of-care treatment on their expression and antitumor immunity in esophageal squamous cell carcinoma (ESCC) remains unclear. We evaluated the adenosine axis in the context of neoadjuvant therapy received and its relationship to immune markers in ESCC tumor samples.

Methods

Samples from patients who underwent surgical resection at the National Cancer Center Hospital, Tokyo, Japan, between January 2002 and July 2019 following no neoadjuvant therapy (n = 55; treatment-naïve), chemotherapy (n = 200), or chemoradiotherapy (CRT; n = 20) were immunohistochemically stained for CD73, CD39, PD-L1, FoxP3, and CD8; markers were quantified across tumor microenviron

SUBMITTER: Cooper ZA 

PROVIDER: S-EPMC11954769 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature