FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis.

ABSTRACT:

Introduction

Sepsis, a systemic immune syndrome caused by severe trauma or infection, poses a substantial threat to the health of patients worldwide. The progression of sepsis is heavily influenced by septic liver injury, which is triggered by infection and cytokine storms, and has a significant impact on the tolerance and prognosis of septic patients. The objective of our study is to elucidate the biological role and molecular mechanism of fibroblast growth factor 21 (FGF21) in the process of sepsis.

Objectives

This study was undertaken in an attempt to elucidate the function and molecular mechanism of FGF21 in therapy of sepsis.

Methods

Serum concentrations of FGF21 were measured in sepsis patients and septic mice. Liver injury was compared between mice FGF21 knocko

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11954821 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature