The impact of initiation timing of continuous renal replacement therapy on outcomes in critically ill patients with acute kidney injury a retrospective study from the MIMIC-IV database.

ABSTRACT: Acute kidney injury (AKI) is common in critically ill patients, optimal timing for initiation of renal replacement therapy (RRT) for AKI but without life-threatening indications is unclear. A retrospective study was performed using the medical information mart for intensive care (MIMIC-IV), including AKI patients identified based on kidney disease improving global outcomes (KDIGO) definition. The time to initiate CRRT was defined as the interval from first diagnosis of AKI to the initiation of CRRT, analyzed as a continuous variable. The primary outcome was 28-day mortality, restricted cubic splines (RCS) to assess the relationship between CRRT initiation timing intervals and clinical outcomes. The study included 673 patients, with a 28-day mortality rate of 38.78%. RCS analysis revealed n

SUBMITTER: Nuermaimaiti M 

PROVIDER: S-EPMC11954857 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature