Association between COVID-19 and the development of chronic kidney disease in patients without initial acute kidney injury.

ABSTRACT: While the association between COVID-19 and acute kidney injury (AKI) is well documented, the impact of COVID-19 on the development of advanced chronic kidney disease (CKD) remains unclear, particularly in patients without initial AKI. Using the TriNetX healthcare database, we conducted a matched cohort study comparing 141,587 COVID-19 and 141,587 influenza patients. We excluded patients with AKI within one month of infection and matched groups on demographics, comorbidities, and baseline laboratory values. The primary outcome was the incidence of advanced CKD (stages 3-5) at the 12-month follow-up. COVID-19 patients showed higher 12-month risks of advanced CKD (hazard ratio [HR]:2.02, 95% confidence interval [CI]:1.69-2.42, p < 0.0001), AKI (HR 3.04, 95%CI:2.61-3.55, p < 0.0001), and estim

SUBMITTER: Chen IW 

PROVIDER: S-EPMC11954888 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature