Characteristics, outcome, and prognostic factors of young patients with central nervous system World Health Organization grade 3 oligodendrogliomas IDH-mutant and 1p/19q codeleted: A French POLA network study.

ABSTRACT:

Background

Brain tumors represent one of the main causes of cancer-related mortality in young patients. Among them, oligodendrogliomas (OG) are adult-type diffuse gliomas with the best prognosis. Nevertheless, characterization of these tumors in the young population remains poorly documented. Our objective was to characterize the population of young adults under 40 years of age with grade 3 OG in the POLA cohort.

Methods

Clinical data prospectively collected for all patients registered with grade 3 OG between April 2009 and August 2021 were extracted from the national POLA database. This study compared the patient subgroup <40 years of age to the one >40 years of age.

Results

The authors included 111 patients <40 years old and 363 patients ≥40 years old. Treatment rec

SUBMITTER: Bertucci A 

PROVIDER: S-EPMC11955080 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature