Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver.

ABSTRACT: Hepatic metabolism involving pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) may be abnormal in fatty livers. In this study, [¹³C]bicarbonate production from [1-¹³C₁]pyruvate in the liver and glycerol glyceroneogenesis were examined in relation to hepatic fat content using hyperpolarized [1-¹³C₁]pyruvate and oral [U-¹³C₃]glycerol. After an overnight fast, 15 subjects with a range of hepatic fat content received hyperpolarized [1-¹³C₁]pyruvate intravenously to assess its conversion to [1-¹³C₁]lactate and [¹³C]bicarbonate in the liver. They also received oral [U-¹³C₃]glycerol, followed by venous blood sampling to examine glucose

SUBMITTER: Park JM 

PROVIDER: S-EPMC11955189 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature