Cell-Material Interactions in Covalent Adaptable Thioester Hydrogels.

ABSTRACT: Covalent adaptable networks (CANs) are polymeric networks with cross-links that can break and reform in response to external stimuli, including pH, shear, and temperature, making them potential materials for use as injectable cell delivery vehicles. In the native niche, cells rearrange the extracellular matrix (ECM) to undergo basic functions including migration, spreading, and proliferation. Bond rearrangement enables these hydrogels to mimic viscoelastic properties of the native ECM which promote migration and delivery from the material to the native tissue. In this work, we characterize thioester CANs to inform their design as effective cell delivery vehicles. Using bulk rheology, we characterize the rearrangement of these networks when they are subjected to strain, which mimics the str

SUBMITTER: Desai S 

PROVIDER: S-EPMC11955190 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature