Modeling meibum secretion: Alternatives for obstructive Meibomian Gland Dysfunction (MGD).

ABSTRACT:

Purpose

While changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion. The purpose of this study was to develop a finite element model of meibum secretion and evaluate the effect of various factors that might impact meibum delivery to the ocular surface.

Methods

A finite element analysis in COMSOL 6.0 was used to simulate the flow of meibum within the gland's terminal excretory duct. Historical normal human meibum rheology data taken over the meibum melting range from fluid (35-40 °C) to solid (25-30 °C) were then used to calculate the minimum yield stress and plastic viscosity of meibum. The effects of meibum melting state, eyelid pressure and terminal duct d

SUBMITTER: Luo S 

PROVIDER: S-EPMC11955202 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature