Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish.

ABSTRACT: Isopropylated phenyl phosphates (IPP) are an additive organophosphate flame retardant (OPFR) that has been extensively used in furniture, electronics, automobiles, plastics, and children's products to slow down the spread of fire but its continued leaching leads to toxicity concerns. Toxicological information on this important legacy contaminant is limiting. Using zebrafish, our prior whole embryonic RNA-seq data revealed disruption of gene sets enriched for DNA methylation, neurotransmitter synthesis, retinoic acid signaling and eye development. Within this study, we used zebrafish embryos to systemically study these biological targets. Our initial range-finding experiments revealed significant morphological impacts like pericardial edema, yolk sac edema and spinal curvature, coupled with

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11955206 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature