Endomyocardial biopsy in the diagnosis of cardiac sarcoidosis.

ABSTRACT:

Aims

We set out to assess the utility of endomyocardial biopsy (EMB) in cardiac sarcoidosis (CS). Historically, EMB sensitivity in CS is only ≤25%, but comprehensive analyses of its current diagnostic performance are not available.

Methods and results

The data of 260 consecutive patients with CS (mean age 49 years, 60% female) meeting the Heart Rhythm Society diagnostic criteria were analysed retrospectively. Overall, 216 patients (83%) had undergone EMB, 47 with repeat procedures. EMB overall sensitivity was 38%, rising to 49% after repeat biopsies. On logistic regression analysis, positive EMB was predicted independently by presentation with ventricular tachyarrhythmia with an odds ratio (OR) of 3.8 (95% confidence interval [CI] 1.2-12.0, p = 0.021), left ventricular eject

SUBMITTER: Malkonen H 

PROVIDER: S-EPMC11955311 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature