Cognitive impairment following maternal separation in rats mediated by the NAD⁺/SIRT3 axis via modulation of hippocampal synaptic plasticity.

ABSTRACT: Maternal separation (MS) during early life can induce behaviors in adult animals that resemble those seen in schizophrenia, manifesting cognitive deficits. These cognitive deficits may be indicative of oxidative stress linked to mitochondrial dysfunction. However, there is limited understanding of the molecular mechanisms regulating mitochondria in neural circuits that govern cognitive impairment relevant to schizophrenia, and their impact on neuronal structure and function. A 24-h MS rat model was utilized to simulate features associated with schizophrenia. Schizophrenia-associated behaviors and cognitive impairment were assessed using the open field test, pre-pulse inhibition, novel object recognition test, and Barnes maze test. The levels of mitochondrial proteins were measured using we

SUBMITTER: Hao K 

PROVIDER: S-EPMC11955552 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature