Alkyne dimerization-hydroarylation to form pentasubstituted 1,3-dienes via binuclear nickel catalysis.

ABSTRACT: Mono-metallic catalysts dominate in homogeneous catalysis, wherein all the element steps generally occur on one metal site. Inspired from bimetallic active sites in both enzymes and heterogeneous catalysts, the development of binuclear catalysis can offer the potential to induce novel intermediates, reactivity, and selectivity. Metal-catalyzed hydroarylation of alkynes generally leads to one alkyne incorporated products and alkyne dimerization-hydrocarbofunctionalization is rather challenging via conventional mono-metallic intermediates. Herein, a highly selective dimerization-hydrocarbofunctionalization of internal alkynes is achieved via dinickel catalysis, leading to the formation of synthetically challenging pentasubstituted 1,3-dienes. Mechanistic studies suggest that each Ni site can

SUBMITTER: Chen K 

PROVIDER: S-EPMC11955554 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature