Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway.

ABSTRACT:

Introduction

Glioblastoma multiform (GBM) is considered the deadliest brain cancer. Standard therapies are followed by poor patient's survival outcomes, so novel and more efficacious therapeutic strategies are imperative to tackle this scourge. Metformin has been reported to have anti-cancer effects. However, the precise mechanism underlying these effects remains elusive. A better understanding of its underlying mechanism will inform future experimental designs exploring metformin as a potential adjuvant therapy for GBM. This research aimed to elucidate the potential molecular mechanism of metformin in GBM by integrating proteomics and transcriptomics.

Methods

The study examined the effects of metformin on GBM cell lines using various methods. The U87, U251 and HA1800 were c

SUBMITTER: Li H 

PROVIDER: S-EPMC11955593 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature