Preoperative donor urinary UDP-Glc as an independent risk factor for delayed graft function.

ABSTRACT:

Background

Expanded criteria donors (ECD) have the potential to greatly increase the donor organ pool but pose a higher risk of delayed graft function (DGF) post-transplantation. Uridine diphosphate-glucose (UDP-Glc) plays a significant role in extracellular signaling related to tissue damage and retains stability for detection. Donor urinary UDP-Glc level may be an appropriate and effective biomarker for predicting DGF.

Methods

Recipients who underwent successful kidney transplantation, with corresponding collection of donor urine samples, between June 2023 and August 2024 were included. We measured preoperative donor urinary UDP-Glc levels and analyzed their correlation with graft recovery. The study was registered in the Clinical Trial Registry (no. NCT06707272).

Resul

SUBMITTER: Ma M 

PROVIDER: S-EPMC11955600 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature