Strategic delivery of omega-3 fatty acids for modulating inflammatory neurodegenerative diseases.

ABSTRACT:

Objectives

Early-life inflammatory events like infections and injuries may predispose the brain to Alzheimer's disease (AD) by disrupting neurodevelopment and raising vulnerability. The association between early neuroinflammation and subsequent neurodegeneration leading to dementia remains unclear. We hypothesize that omega-3 (n-3) fatty acids (FA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), positively regulate neuro-immune cells, preserving their cell membrane structure and metabolic homeostasis. Our study examined whether strategic delivery of n-3 FA via injectable n-3 triglycerides (TG) can influence microglial lipid metabolism to prevent or delay AD progression.

Methods and results

We characterized n-3 treatment effects on modulating lipid and

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11955621 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature