Immunoglobulin G <i>N</i>-Glycome as a biomarker of mortality risk in <i>Escherichia coli</i> induced sepsis.

ABSTRACT:

Background

Sepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis. The role of immunoglobulin G N-glycome in estimating the mortality in patients with sepsis remains unknown. This study aims to reveal the clinical application of immunoglobulin G N-glycome as a potentially novel biomarker to predict mortality risk in Escherichia coli-induced sepsis.

Methods

The serum immunoglobulin G N-glycome levels in 100 adult septic patient serum samples on the day of intensive care unit (ICU) admission, and 100 healthy volunteers were measured and analyzed. Immunoglobulin G N-glycome was compared with

SUBMITTER: Wang H 

PROVIDER: S-EPMC11955649 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature