Resveratrol prevents gallstones in mice fed on a high fat diet via regulating PPAR-γ and SR-BI.

ABSTRACT:

Background

With the gradual improvement of living standards, the incidence of gallstones is getting higher and higher, and cholesterol gallstones (CG) are the most prevalent subtype. Therefore, we urgently need a better way to treat gallstones.

Objective

This study aimed to evaluate the effects of resveratrol (Res) on cholesterol gallstone formation and explore its underlying mechanisms, focusing on its modulation of hepatic peroxisome proliferator-activated receptor γ (PPAR-γ) expression, bile cholesterol saturation, and hepatic cholesterol metabolism.

Methods

Thirty-two male C57BL/6 mice were randomly divided into four groups: control, model, ursodeoxycholic acid (UDCA), and Res groups. Res (100 mg/kg/day) and UDCA (100 mg/kg/day) were administered via gavage for 5 

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11955665 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature