Disruption of structural connectome hierarchy in age-related hearing loss.

ABSTRACT:

Introduction

Age-related hearing loss (ARHL) is a common sensory disability among older adults and is considered a risk factor for the development of dementia. Previous work has shown altered brain connectome topology in ARHL, including abnormal nodal strength and clustering coefficient. However, whether ARHL affects the hierarchical organization of structural connectome and how these alterations relate to transcriptomic signatures remain unknown.

Methods

Here, we apply a gradient mapping framework to the structural connectome derived from diffusion magnetic resonance imaging. We focus on the first three structural gradients that reflect distinct hierarchical organization of structural connectome, and assess ARHL-related changes.

Results

We find that, compared to cont

SUBMITTER: Zhen Y 

PROVIDER: S-EPMC11955685 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature