Systematic Review of Management Strategies for Alport Syndrome: Implications for Male Patients.

ABSTRACT:

Background and aims

Alport Syndrome (AS) is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and ocular abnormalities, with an incidence of approximately 1 in 50,000 newborns. Due to the severity of the disease, particularly in males with X-linked inheritance, this systematic review consolidates current management strategies, highlighting advancements and existing gaps in treatment options.

Methods

This systematic review followed a protocol registered on the OSF platform (osf. io/k86ms). A comprehensive search of PubMed, Web of Science, Scopus, Cochrane Library, Embase, ClinicalTrials.gov, and the WHO ICTRP was completed by December 24, 2023. Studies eligible for inclusion were clinical trials or observational studies evaluating AS managemen

SUBMITTER: Sarfraz Z 

PROVIDER: S-EPMC11955716 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature