Mechanism of Qigu capsule as a treatment for sarcopenia based on network pharmacology and experimental validation.

ABSTRACT:

Objective

To explore the potential molecular mechanism of Qigu capsule (，QGC) in the treatment of sarcopenia through network pharmacology and to verify it experimentally.

Methods

The active compounds of QGC and common targets between QGC and sarcopenia were screened from databases. Then the herbs-compounds-targets network, and protein-protein interaction (PPI) network was constructed. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed by R software. Next, we used a dexamethasone-induced sarcopenia mouse model to evaluate the anti-sarcopenic mechanism of QGC.

Results

A total of 57 common targets of QGC and sarcopenia were obtained. Based on the enrichment analysis of GO and KEGG, we took the phosphatidylinos

SUBMITTER: Jinyu S 

PROVIDER: S-EPMC11955765 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature