Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube.

ABSTRACT: A macrocyclic arene featuring rigid bis-naphthalene possesses a remarkable ability to strongly bind neostigmine (K _a = 2.7 × 10⁴ M^-1) and pyridostigmine (K _a = 2.2 × 10⁵ M^-1) within its deep cavity. This facilitates the host as a potential ionophore for the potentiometric determination of neostigmine and pyridostigmine with low detection limits of 1.0 μM, highlighting its promising applications in pharmaceutical analysis.

SUBMITTER: Wu JF 

PROVIDER: S-EPMC11955825 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature