Just 1-min exposure to a pure tone at 100 Hz with daily exposable sound pressure levels may improve motion sickness.

ABSTRACT:

Background

Motion sickness is a common transportation issue worldwide. Vestibular dysfunction has been reported to be a key etiology of motion sickness. However, there are limited technologies for alleviating motion sickness.

Methods

The most appropriate frequency (Hz) and level (dBZ) of pure tone for modulation of vestibular function were determined by an ex vivo study using murine utricle explants. The preventive effects of the selected pure tone on motion sickness were then confirmed by using a beam balance test in mice. The alleviating effects of pure tone on motion sickness induced by a swing, driving simulator or real car were objectively assessed by using posturography and electrocardiography (ECG) and were subjectively assessed by using the Motion Sickness Assessment

SUBMITTER: Gu Y 

PROVIDER: S-EPMC11955832 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature